Drug Profile: Aldactone

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ALDACTONE

Substance: spironolactone
Trade Names:
Aldactacine 40 comp	25 mg tab.;	Searle ES
Aldactone	25, 50, 100 mg tab;	Searle S, PT, FI, DK, ES, FR, CH, NL, U.S. Mexico, Panama, Guatemala, El Salvador, Honduras, Dom. Rep., Costa Rica Lepetit 1, Galencia CZ Vianex GR
Aldactone	25, 50 mg drg.;	Boehringer G, A
Aldactone	100 mg cap.;	Boehringer G, A
Aldactone	100 mg tab.;	Searle GR, ES
Aldopur	5 0, 100 mg drg.;	Hormosan G
Aquareduct (o.c.)	50, 100 mg tab.;	Azupharma G
Deverol	50 mg tab.;	Waldheim A
Duraspiron	5 0, 100 mg tab.;	Durachemie G
Jenaspiron	5 0, 100 mg tab.;	Jenapharm G
Osyrol	50, 100 mg tab;	Hoechst G
Spiractone	25, 100 mg tab.;	Elvipi GR
Spiresis	25, 50, 100 mg tab.;	Lkefarmos FI
5pirldon	25, 100 mg tab.;	Orion Fl
Spirix	25, 50, 100 mg tab.;	Benzon Fl, NO; Nycomed DK
Spiroctan	25, 50 mg drg.;	Boehringer CH
Spiroctan	100 mg cap.;	Boehringer CH
Spirohexal	100 mg tab.;	Hexal Pharma A
Spirolang	25, 50, 100 mg cap.;	Sit I
Spirolone	25 mg tab.;	Berk CZ
Spiron	25, 100 mg tab.;	Ercopharm DK
Spirono-ISIS 50/100	50, 100 mg tab.;	ISIS Pharma G
Spironolacton dumex	50, 100 mg tab.;	Dumex NL
Spironolacton Heumann	50, 100 mg tab.;	Heumann G
Spironolacton mp	25, 50 mg, tab.;	MP NO
Spironolacton Stada	50, 100 mg tab.;	Stadapharm G (o.c.)
Spironolacton-- ratiopharm(o.c.)	50, 100 mg. tab.;	ratiopharm G
Spironolactone scher	50, 75 mg tab.;	Scher FR
Spironolactone (o.c.)	50, 100 mg tab.;	Lederle U.S.
Spironolactone (o.c.)	50, 100 mg tab.;	Geneva U.S.
Spironolactone (o.c.)	50, 100 mg tab.;	Warner Chilcott U.S.
Spironolactone	25 mg tab.;	Mylan U.S.
Spironolactonum gf	25, 50, 100 mg tab.;	Gf NL
Spironolactonum pharbita.	25, 50, 100 mg tab.;	Pharbita NL
Spironolakton Bota	25, 5 0, 100 mg tab.;	Bota S
Spironolakton Fermenta	50, 100 mg tab.	Fermenta S
Spironolakton NM Parma	25, 50, 100 mg tab.;	NM Pharma S
Spiro-Tablinen (o.c.)	100 mg tab.;	Sanorana G
Spiro-Tablinen- Tabletten	100 mg tab.;	Wenig A
Verospiron	25 mg tab.;	Hormosan G
Verospiron	50, 100 mg cap.	Hormosan G
Verospiron	25 mg tab.;	Gedeon Richter HU, CZ

Remark: Internationally, numerous other compounds containing the substance spironolactone are available. Due to limited space they are not listed here.

Aldactone is a diuretic and belongs to the subgroup of potassium--sparing diuretics. Aldactone is an aldosterone antagonist. It influ-ences the body's own hormone, aldosterone, which accelerates the excretion of potassium and reduces the excretion of sodium and water. Simplified, aldosterone regulates the endogenous water household. The higher the aldosterone level, the more water is stored in the body. The use of Aldactone results in a significant reduction in the aldosterone level so that an increased excretion of sodium and water occurs while, at the same time, potassium is reabsorbed. This also explains why Aldactone is called a potassium-sparing diuretic since it does not cause a loss of potassium like thiazides and furosemides (lasix) do. Athletes must strictly observe that during the use of Aldactone no additional potassium is taken since this would cause a life-threatening increase in the serum potassium level. Potassium--sparing diuretics have relatively low diuretic effects so that Aldactone can be called a mild diuretic. It is interesting to note that Aldactone is also an antiandrogen since it reduces the androgen level. Female athletes take advantage of this characteristic by using it to minimize the virilization symptoms during steroid treatment or the symptoms after treatment. For this purpose Aldactone is normally taken daily for 10 to14 days, usually in a dose of 50 mg/day. In men this could cause problems since the relationship of the andro-gen level to the estrogen level changes in favor of the latter. Thus, common side effects in men include pain in the nipples and breast swelling (gynecomastia).

Bodybuilders use Aldactone almost exclusively during the last week before a competition. Since this causes neither a dramatic nor an immediately noticeable draining effect, it is usually taken over 5-6 days in a dosage of 2 tablets of 50 mg daily. Both male and female athletes take it. The main problems in men consist of gynecomastia and possible impotence. Other side effects can be low blood pressure, muscle spasms, dizziness, gastrointestinal pain, vomiting, irregular pulse rate, and fatigue.

Aldactone by Boehringer Mannheim of Germany is often found on the black market. A package contains 50 dragees of 50 mg each and costs approx. $30 on the black market. There are currently no Aldactone fakes available.

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